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Karen Watanabe

Karen Watanabe

Associate Professor, School of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences

karen.watanabe@asu.edu

602-543-5811

School of Mathematical and Natural Sciences
Arizona State University, West campus
4701 W. Thunderbird Road
Glendale, AZ 85306

Titles

  • Senior Sustainability Scholar, Julie Ann Wrigley Global Institute of Sustainability
  • Associate Professor, School of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences

Biography

Karen H. Watanabe, PhD is an associate professor in the School of Mathematical and Natural Sciences at Arizona State University, West campus.  She is the program lead for the Pharmacology & Toxicology BS degree.  Her research focuses on developing mathematical models of biological systems to better understand and predict how chemicals in the environment affect living organisms.  Since 2004, her research has focused upon reproductive health both under normal conditions and in response to endocrine active chemicals, and the development of adverse outcome pathway models for predictive toxicology and risk assessment.

Watanabe has received Scientific and Technological Achievement Awards from the U.S. Environmental Protection Agency for research related to modeling endocrine active chemicals and their effects upon reproduction in the context of ecological risk assessment.  She has also participated in national and international workgroups focused on adverse outcome pathways and cancer risk assessment.

Education

  • PhD, Mechanical Engineering, University of California-Berkeley, 1993
  • MS, Mechanical Engineering, University of California-Berkeley, 1990
  • BS, Chemical Engineering, Northwestern University, 1986

Expertise

Journal Articles

2018

Murphy, C. A., R. M. Nisbet, P. Antczak, N. Garcia-Reyero, A. Gergs, K. Lika, T. Mathews, E. B. Muller, D. Nacci, A. Peace, C. H. Remien, I. R. Schultz, L. M. Stevenson and K. H. Watanabe. 2018. Incorporating suborganismal processes into dynamic energy budget models for ecological risk assessment. Integrated Environmental Assessment and Management 14(5):615=624. DOI: 10.1002/ieam.4063.. (link )

Nishimura, J., R. Smith, K. Jensen, G. Ankley and K. H. Watanabe. 2018. Estimating intermittent individual spawning behavior via disaggregating group data. Bulletin of Mathematical Biology 80(3):687-700. DOI: 10.1007/s11538-017-0379-x. (link )

Rowland, M. A., H. Wear, K. H. Watanabe, K. A. Gust and M. L. Mayo. 2018. Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures. BMC Systems Biology 12:Art. 81. DOI: 10.1186/s12918-018-0601-y. (link )

2017

Conolly, R. B., G. T. Ankley, W. Cheng, M. L. Mayo, D. H. Miller, E. J. Perkins, D. L. Villeneuve and K. H. Watanabe. 2017. Quantitative adverse outcome pathways and their application to predictive toxicology. Environmental Science & Technology 51(8):4661-4672. DOI: 10.1021/acs.est.6b06230. (link )

Wear, H. M., A. Eriksson, H. H. Yao and K. H. Watanabe. 2017. Cell-based computational model of early ovarian development in mice. Biology of Reproduction 97(3):365-377. DOI: 10.1093/biolre/iox089. (link )

2016

Watanabe, K. H., M. Mayo, K. M. Jensen, D. L. Villeneuve, G. T. Ankley and E. J. Perkins. 2016. Predicting fecundity of fathead minnows (Pimephales promelas) exposed to endocrine-disrupting chemicals using a MATLAB®-based model of oocyte growth dynamics. PLOS One 11(1):e0146594. DOI: 10.1371/journal.pone.0146594. (link )

Wear, H. M., M. J. McPike and K. H. Watanabe. 2016. From primordial germ cells to primordial follicles: A review and visual representation of early ovarian development in mice. Journal of Ovarian Research 9(Art 36):. DOI: 10.1186/s13048-016-0246-7. (link )

2015

Groh, K. J., R. N. Carvalho, J. K. Chipman, N. D. Denslow, M. Halder, C. A. Murphy, D. Roelofs, A. Rolaki, K. Schirmer and K. H. Watanabe. 2015. Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology. Chemosphere 120(Feb):764-777. DOI: 10.1016/j.chemosphere.2014.09.068. (link )

Groh, K. J., R. N. Carvalho, J. K. Chipman, N. D. Denslow, M. Halder, C. A. Murphy, D. Roelofs, A. Rolaki, K. Schirmer and K. H. Watanabe. 2015. Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish. Chemosphere 120(Feb):778-792. DOI: 10.1016/j.chemosphere.2014.10.006. (link )

2013

Breen, M., D. L. Villeneuve, G. T. Ankley, D. C. Bencic, M. S. Breen, K. H. Watanabe, A. L. Lloyd and R. B. Conolly. 2013. Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aramatase inhibition: II. Computational modeling. Toxicological Sciences 133(2):234-247. DOI: 10.1093/toxsci/kft067. (link )

2012

Villeneuve, D. L., N. Garcia-Reyero, D. Martinovic-Weigelt, Z. Li, K. H. Watanabe, E. F. Orlando, C. A. LaLone, S. W. Edwards, L. D. Burgoon, N. D. Denslow, E. J. Perkins and G. Ankley. 2012. A graphical systems model and tissue-specific functional gene sets to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746(2):151-162. DOI: 10.1016/j.mrgentox.2011.12.016. (link )

2011

Johns, S. M., N. D. Denslow, M. D. Kane, K. H. Watanabe, E. F. Orlando and M. S. Sepulveda. 2011. Effects of estrogens and antiestrogens on gene expression of fathead minnow (Pimephales promelas) early life stages. Environmental Toxicology 26(2):195-206. DOI: 10.1002/tox.20545. (link )

Li, Z., K. J. Kroll, K. Jensen, D. L. Villeneuve, G. T. Ankley, J. V. Brian, M. S. Sepulveda, E. F. Orlando, J. M. Lazorchak, M. Kostich, B. Armstrong, N. D. Denslow and K. H. Watanabe. 2011. A computational model of the hypothalamic-pituitary-gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone. BMC Systems Biology 5:Art. 63. DOI: 10.1186/1752-0509-5-63. (link )

Li, Z., D. L. Villeneuve, K. M. Jensen, G. T. Ankley and K. H. Watanabe. 2011. A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish. Canadian Journal of Fisheries and Aquatic Sciences 68(9):1528-1538. DOI: 10.1139/f2011-066. (link )

Watanabe, K. H., M. E. Andersen, N. Basu, M. J. Carvan III, K. M. Crofton, K. A. King, C. Sunol, E. Tiffany-Castiglioni and I. R. Schultz. 2011. Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study. Environmental Toxicology and Chemistry 30(1):9-21. DOI: 10.1002/etc.373. (link )

2009

Watanabe, K. H., M. V. Djordjevic, S. D. Stellman, P. L. Toccalino, D. F. Austin and J. F. Pankow. 2009. Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data. Regulatory Toxicology and Pharmacology 55(2):123-133. DOI: 10.1016/j.yrtph.2009.06.007. (link )