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George Stephanopoulos

George Stephanopoulos

Director, The Global KAITEKI Center

gstepha2@asu.edu

480-965-3294

School of Molecular Sciences
Arizona State University
PO Box 871604
Tempe, AZ 85287-1604

Titles

  • Senior Sustainability Scientist, Julie Ann Wrigley Global Institute of Sustainability
  • Director, The Global KAITEKI Center
  • Professor, School of Molecular Sciences/School for the Engineering of Matter, Transport and Energy, College of Liberal Arts and Sciences/Ira A. Fulton Schools of Engineering
  • Associate Faculty, Biodesign Center for Molecular Design & Biomimetics, Biodesign Institute

Biography

George Stephanopoulos joined Arizona State University in January 2018 and holds a joint appointment as professor at the School of Molecular Sciences and the School for Engineering of Matter, Transport and Energy. He is also the Arthur D. Little Post-Tenure Professor of Chemical Engineering at the Massachusetts Institute of Technology.

His research and teaching interests have covered many aspects of process systems engineering, such as: process synthesis; process modeling and analysis; process optimization; process operations modeling, analysis, diagnosis, and control; process operations scheduling and planning. His systems engineering interests led him into a variety of other types of systems, addressing research issues related to the design, analysis, control, optimization of the corresponding systems:  networks of chemical or biochemical reactions; integrated manufacturing systems within the scope of a national economy or corporate business; city traffic networks and intercity transportation networks; systems approaches to the design and manufacturing of products; and process systems engineering for integrated nanoscale processes.

He received his diploma in chemical engineering from National Technical University of Athens in 1970, and his ME from McMaster University in 1971. During 1971-74, he worked with Art Westerberg at the University of Florida on his doctorate. He then joined the University of Minnesota as an assistant professor of chemical engineering. He was promoted to associate professor in 1977 and professor in 1981. In September of 1980, he took on a chaired professorship at his Greek alma matta and taught there until January 1984, when he joined the faculty at MIT; first as the J. R. Mares and then as the A. D. Little Professor of Chemical Engineering. During 2000-02, he took a leave of absence from MIT and was appointed chief technology officer and managing executive officer of Mitsubishi Chemical Corporation (MCC). Upon his return to MIT, he continued as managing director, member of the Board of MCC until 2005.

He is a member of the National Academy of Engineering (1999), Foreign Member of Russian Academy of Technological Sciences (1991), and a fellow of the American Academy of Arts and Sciences (2012). He received an Honorary Doctor of Science degree from McMaster University (2002). In 2009 he received the Ragazzini Award, of the American Automatic Control Council (AACC), 2009He is a fellow of American Institute of Chemical Engineers (AlChE) and has received the Walker (’03) and Colburn (’82) awards. He was also the 2003 AIChE Institute Lecture and one of the 100 Chemical Engineers of Modern Era. He received the 1993 Computing in Chemical Engineering Award, from AIChE’s CAST Division. He has also received the C. McGraw Award for Research from American Society for Engineering Education (’86) and the 1977 Dreyfus Teacher and Scholar Award. The journal Computers and Chemical Engineering selected his papers twice for the Best Paper Award (1987, 1992). He has given honorary lectureships at Princeton University (Wilhelm Lectures, 2009); ETH-Zurich (Stodola Medal Lecture, 2009);  Univ. of Delaware (Gerster Lecture, 2004); Imperial College (Sargent Lecture, 2000); Carnegie Mellon (2000); Purdue Univ. (Kelly Lectures, 1999); Univ. of Oklahoma (Fair Lecture, 1999); Rutgers Univ. (Merck Distinguished Lecture, 1992); CCNY (Katz Memoral Lecture, 1989); Univ.of Newcastle (The ICI Distinguished Lecture, 1988); Univ. of Bologna (Distinguished Lecturer for the 900th Anniversary, 1988); Caltech (The Dreyfus Lectures, 1982), and others.

Stephanopoulos has authored/co-authored seven books and co-edited eight.  He is co-author to more than 210 papers.

Education

  • PhD, University of Florida, 1974
  • ME, McMaster University, Canada, 1971
  • Diploma, Chemical Engineering, National Technical University of Athens, Greece, 1970

Expertise

Journal Articles

2016

Ines Torres, A. and G. W. Stephanopoulos. 2016. Design of multi‐actor distributed processing systems: A game‐theoretical approach. AIChE Journal 62(9):3369-3391. DOI: 10.1002/aic.15395. (link )

2015

Ramaswamy, S., P. I. Barton and G. W. Stephanopoulos. 2015. Controlled formation of nanostructures with desired geometries. Part 4. Multiresolution optimal control in dynamically directed self-assembly of nanoparticles. I&EC Research 54(34):8520-8532. DOI: 10.1021/acs.iecr.5b01586. (link )

Ramaswamy, S., R. Lakerveld, P. I. Barton and G. Stephanopoulos. 2015. Controlled formation of nanostructures with desired geometries. Part 3. Dynamic modeling and simulation of directed self-assmebly of nanoparticles through adapative finite state projection. I&EC Research 54(16):4371-4384. DOI: 10.1021/ie504182w. (link )

2014

Leveson, N. G. and G. Stephanopoulos. 2014. A system‐theoretic, control‐inspired view and approach to process safety. AIChE Journal 60(1):2-14. DOI: 10.1002/aic.14278. (link )

Stephanopoulos, G. 2014. Laying the foundations: An advisor's perspective. Computer & Chemical Engineering 70(Nov):3-10. DOI: 10.1016/j.compchemeng.2014.05.016. (link )

2012

Lakerveld, R., G. Stephanopoulos and P. I. Barton. 2012. A master-equation approach to simulate kinetic traps during directed self-assembly. The Journal of Chemical Physics 136(18):184109. DOI: 10.1063/1.4716190. (link )

2011

Stephanopoulos, G. W. and G. V. Reklaitis. 2011. Process systems engineering: From Solvay to modern bio- and nanotechnology.: A history of development, successes and prospects for the future. Chemical Engineering Science 66(19):4272-4306. DOI: 10.1016/j.ces.2011.05.049. (link )

2010

Solis, E. O., P. I. Barton and G. W. Stephanopoulos. 2010. Controlled formation of nanostructures with desired geometries. 1. Robust static structures. I&EC Research 49(17):7728-2245. DOI: 10.1021/ie100066v. (link )

Solis, E. O., P. I. Barton and G. W. Stephanopoulos. 2010. Controlled formation of nanostructures with desired geometries. 2. Robust dynamic paths. I&EC Research 49(17):7746-7757. DOI: 10.1021/ie1000778. (link )

2008

Stephanopoulos, G., O. Karsligil and M. S. Dyer. 2008. Multiscale theory for linear dynamic processes: Part 1. Foundations. Computers & Chemical Engineering 32(4-5):857-884. DOI: 10.1016/j.compchemeng.2007.03.021. (link )

Stephanopoulos, G. W., O. Karsligil and M. Dyer. 2008. Multiscale theory for linear dynamic processes: Part 2. Multiscale model predictive control (MS-MPC). Computers & Chemical Engineering 32(4-5):885-912. DOI: 10.1016/j.compchemeng.2007.03.022. (link )

2007

Misra, J., I. Alevizos, D. Hwang, G. Stephanopoulos and G. Stephanopoulos. 2007. Linking physiology and transcriptional profiles by quantitative predictive models. Biotechnology and Bioengineering 98(1):252-260. DOI: 10.1002/bit.21540. (link )

2005

Camelo, S., A. H. Iglesias, D. Hwang, B. Due, H. Ryu, K. M. Smith, S. G. Gray, J. Imitola, G. Duran, B. Assaf, B. Langley, S. J. Khoury, G. Stephanopoulos, U. De Girolami, R. R. Ratan, R. J. Ferrante and F. Dangond. 2005. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 164(1-2):10-21. DOI: 10.1016/j.jneuroim.2005.02.022. (link )

Ismail, A. E., G. C. Rutledge and G. Stephanopoulos. 2005. Topological coarse graining of polymer chains using wavelet-accelerated Monte Carlo. I. Freely jointed chains. Journal of Chemical Physics 122:234901. DOI: 10.1063/1.1924480. (link )

Ismail, A. E., G. C. Rutledge and G. Stephanopoulos. 2005. Using wavelet transforms for multiresolution materials modeling. Computres & Chemical Engineering 29(5):4. DOI: 10.1016/j.compchemeng.2004.09.015. (link )

Ismail, A. E., G. Stephanopoulos and G. C. Rutledge. 2005. Topological coarse graining of polymer chains using wavelet-accelerated Monte Carlo. II. Self-avoiding chains. Journal of Chemical Physics 122(23):234902. DOI: 10.1063/1.1924481. (link )

Ismail, A. E., G. Stephanopoulos and G. C. Rutledge. 2005. Wavelet‐accelerated Monte Carlo sampling of polymer chains. Journal of Polymer Science: Part B. Polymer Physics 43(8):897-910. DOI: 10.1002/polb.20382. (link )

Stephanopoulos, N., E. O. Solis and G. Stephanopoulos. 2005. Nanoscale process systems engineering: Toward molecular factories, synthetic cells, and adaptive devices. AIChE Journal 51(2):1858-1869. DOI: 10.1002/aic.10618. (link )

2004

Dangond, F., D. Hwang, S. Camelo, P. Pasinelli, M. P. Frosch, G. Stephanopoulos, G. Stephanopoulos, R. H. Brown Jr and S. R. Gullans. 2004. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiological Genomics 16(2):229-239. DOI: 10.1152/physiolgenomics.00087.2001. (link )

Hwang, D., G. Stephanopoulos and C. Chan. 2004. Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function. Bioinformatics 20(4):487-499. DOI: 10.1093/bioinformatics/btg433. (link )

Iglesias, A. H., S. Camelo, D. Hwang, R. Villanueva, G. Stephanopoulos and F. Dangond. 2004. Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. Journal of Neuroimmunology 150(1-2):63-177. DOI: 10.1016/j.jneuroim.2004.01.017. (link )

Lee, K., D. Hwang, T. Yokoyama, G. Stephanopoulos, G. N. Stephanopoulos and M. L. Yarmush. 2004. Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. Bioinformatics 20(6):959-969. DOI: 10.1093/bioinformatics/bth015. (link )

2003

Chan, C., D. Hwang, G. Stephanopoulos, M. L. Yarmush and G. Stephanopoulos. 2003. Application of multivariate analysis to optimize function of cultured hepatocytes. Biotechnology Progress 19(2):580-598. DOI: 10.1021/bp025660h. (link )

Hwang, D., I. Alevizos, W. A. Schmitt, J. Misra, H. Ohyama, R. Todd, M. Mahadevappa, J. A. Warrington, G. Stephanopoulos, D. T. Wong and G. Stephanopoulos. 2003. Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling. Oral Oncology 39(3):259-268. DOI: 10.1016/S1368-8375(02)00108-2. (link )

Ismail, A. E., G. C. Rutledge and G. Stephanopoulos. 2003. Multiresolution analysis in statistical mechanics. I. Using wavelets to calculate thermodynamic properties. Journal of Chemical Physics 118(10):4414. DOI: 10.1063/1.1543581. (link )

Ismail, A. E., G. Stephanopoulos and G. C. Rutledge. 2003. Multiresolution analysis in statistical mechanics. II. The wavelet transform as a basis for Monte Carlo simulations on lattices. The Journal of Chemical Physics 118(10):4424. DOI: 10.1063/1.1543582. (link )

2002

Hwang, D., W. A. Schmitt, G. Stephanopoulos and G. Stephanopoulos. 2002. Determination of minimum sample size and discriminatory expression patterns in microarray data. Bioinformatics 18(9):1184-1193. DOI: 10.1093/bioinformatics/18.9.1184. (link )

Misra, J., W. A. Schmitt, D. Hwang, L. Hsiao, S. R. Gullans, G. Stephanopoulos and G. Stephanopoulos. 2002. Interactive exploration of microarray gene expression patterns in a reduced dimensional space. Genome Research 12:1112-1120. DOI: 10.1101/gr.225302. (link )

Song, J., G. Stephanopoulos and W. H. Green. 2002. Valid parameter range analyses for chemical reaction kinetic models. Chemical Engineering Science 57(21):4475-4491. DOI: 10.1016/S0009-2509(02)00416-5. (link )

Stephanopoulos, G., D. Hwang, W. A. Schmitt, J. Misra and G. Stephanopoulos. 2002. Mapping physiological states from microarray expression measurements. Bioinformatics 18(8):1054-1063. DOI: 10.1093/bioinformatics/18.8.1054. (link )

2001

Hsiao, L., F. Dangond, T. Yoshida, R. Hong, R. V. Jensen, J. Misra, W. Dillon, K. F. Lee, K. E. Clark, P. Haverty, Z. Weng, G. L. Mutter, M. P. Frosch, M. E. MacDonald, E. L. Milford, C. P. Crum, R. Bueng, R. E. Pratt, M. Mahadevappa, J. A. Warrington, G. Stephanopoulos, G. Stephanopoulos and S. R. Gullans. 2001. A compendium of gene expression in normal human tissues. Physiological Genomes 7(2):97-104. DOI: 10.1152/physiolgenomics.00040.2001. (link )

1999

Foss, A. S., K. R. Geurts, R. J. Goodeve, K. D. Dahm, G. Stephanopoulos, J. Bieszczad and A. Koulouris. 1999. A phenomena-oriented environment for teaching process modeling: Novel modeling software and its use in problem solving. Chemical Engineering Education 33(4):292-299. (link )

Stephanopoulos, G., S. Ali, A. Linninger and E. Salomone. 1999. Batch process development: From reactions to manufacturing systems. Computers & Chemical Engineering 23(Supple. 1):S975-S984. DOI: 10.1016/S0098-1354(99)80232-4. (link )

1998

Carrier, J. F. and G. Stephanopoulos. 1998. Wavelet‐based modulation in control‐relevant process identification. AIChE Journal 44(2):341-360. DOI: 10.1002/aic.690440212. (link )

Linninger, A. A., E. Salomone, S. A. Ali, E. Stephanopoulos and G. Stephanopoulos. 1998. Pollution prevention for production systems of energetic materials. Waste Management 17(2-3):165-173. DOI: 10.1016/S0956-053X(97)10017-4. (link )

Linninger, A. and G. Stephanopoulos. 1998. A natural language approach for the design of batch operating procedures. Informatica 27(4):423-434. (link )

Ng, C. and G. Stephanopoulos. 1998. Plant-wide control structures and strategies. IFAC Proceedings Volumes 31(11):1-16. DOI: 10.1016/S1474-6670(17)44899-3. (link )

Realff, M. J. and G. Stephanopoulos. 1998. An the application of explanation-based learning to acquire control knowledge for branch and bound algorithms. INFORMS Journal of Computing 10(1):1-120. DOI: 10.1287/ijoc.10.1.56. (link )

Saraiva, P. M. and G. Stephanopoulos. 1998. Process improvement: An exploratory data analysis approach within an interval-based optimization framework. Production and Operations Management 7(1):19-37. DOI: 10.1111/j.1937-5956.1998.tb00436.x. (link )

Stephanopoulos, G., O. Karsligil and M. Dyer. 1998. Multi-scale aspects in model-predictive control. IFAC Proceedings Volumes 31(11):53-59. DOI: 10.1016/S1474-6670(17)44906-8. (link )

1997

Stephanopoulos, G., M. Dyer and O. Karsligil. 1997. Multi-scale modeling, esimation and control of processing systems. Computers & Chemical Engineering 21(Supple.):S797-S803. DOI: 10.1016/S0098-1354(97)87600-4. (link )

1996

Bakshi, B. R. and G. Stephanopoulos. 1996. Compression of chemical process data by functional approximation and feature extraction. AIChE Journal 42(2):477-492. DOI: 10.1002/aic.690420217. (link )

Linninger, A., S. Ali and G. Stephanopoulos. 1996. Knowledge-based validation and waste management of batch pharmaceutical process designs. Computers & Chemical Engineering 20(Supple. 2):S1431-S1436. DOI: 10.1016/0098-1354(96)00245-1. (link )

Locher, G., B. R. Bakshi, G. Stephanopoulos, G. Stephanopoulos and K. Schugerl. 1996. Ein Ansatz zur automatischen Umwandlung von Rohdaten in Regeln. Teil 2: Eine Fallstudie. Automatisierungstechnik 44(3):138-145. DOI: 10.1524/auto.1996.44.3.138. (link )

Locher, G., G. Stephanopoulos, G. Stephanopoulos and K. Schugerl. 1996. Ein Ansatz zur automatischen Umwandlung von Rohdaten in Regeln Teil 1: Prozeßtrends, Wavelet-transformation und Klassifizierungsbäume. Automatisierungstechnik 44(2):61-70. DOI: 10.1524/auto.1996.44.2.61.. (link )

Ng, C. and G. Stephanopoulos. 1996. Synthesis of control systems for chemical plants. Computers & Chemical Engineering 20(Supple. 2):S999-S1004. DOI: 10.1016/0098-1354(96)00174-3. (link )

Stephanopoulos, G. and C. Han. 1996. Intelligent systems in process engineering: A review. Computers & Chemical Engineering 20(6-7):743-791. DOI: 10.1016/0098-1354(95)00194-8. (link )

1995

Han, C., J. M. Douglas and G. Stephanopoulos. 1995. Agent-based approach to a design support system for the synthesis of continuous chemical processes. Computers & Chemical Engineering 19(Supple. 1):63-69. DOI: 10.1016/0098-1354(95)87016-4. (link )

Linninger, A. A., E. Stephanopoulos, S. A. Ali, C. Han and G. Stephanopoulos. 1995. Generation and assessment of batch processes with ecological considerations. Computers & Chemical Engineering 19(Supple. 1):7-13. DOI: 10.1016/0098-1354(95)87007-5. (link )

1994

Bakshi, B. R., G. Locher, G. Stephanopoulos and G. Stephanopoulos. 1994. Analysis of operating data for evaluation, diagnosis and control of batch operations. Journal of Process Control 4(4):179-194. DOI: 10.1016/0959-1524(94)80040-5. (link )

Bakshi, B. R. and G. Stephanopoulos. 1994. Representation of process trends — IV. Induction of real-time patterns from operating data for diagnosis and supervisory control. Computers & Chemical Engineering 18(4):303-332. DOI: 10.1016/0098-1354(94)85029-1. (link )

Fornari, T. and G. Stephanopoulos. 1994. Synthesis of chemical reaction paths: Economic and specification constraints. Chemical Engineering Communications 129(1):159-182. DOI: 10.1080/00986449408936257. (link )

Fornari, T. and G. Stephanopoulos. 1994. Synthesis of chemical reaction paths: The scope of group contribution methods. Chemical Engineering Communications 129(1):135-157. DOI: 10.1080/00986449408936256. (link )

1993

Bakshi, B. R. and G. Stephanopoulos. 1993. Wave‐net: A multiresolution, hierarchical neural network with localized learning. AIChE Journal 39(1):57-81. DOI: 10.1002/aic.690390108. (link )

1992

Mavrovouniotis, M. L. and G. Stephanopoulos. 1992. Synthesis of reaction mechanisms consisting of reversible and irreversible steps. 1. A synthesis approach in the context of simple examples. Industrial and Engineering Chemistry Research 31(7):1625-1637. DOI: 10.1021/ie00007a009. (link )

Mavrovouniotis, M. L., G. Stephanopoulos and G. Stephanopoulos. 1992. Synthesis of biochemical production routes. Computers & Chemical Engineering 16(5):605-619. DOI: 10.1016/0098-1354(92)80071-G. (link )

Meadowcroft, T. A., G. Stephanopoulos and C. Browsilow. 1992. The modular multivariable controller: I: Steady‐state properties. AIChE Journal 38(8):1254-1278. DOI: 10.1002/aic.690380812. (link )

Saraiva, P. M. and G. Stephanopoulos. 1992. Continuous process improvement through inductive and analogical learning. AIChE Journal 38(2):161-183. DOI: 10.1002/aic.690380202. (link )

1990

Calandranis, J., G. Stephanopoulos and S. Nunokawa. 1990. Diad-kit/boiler. On-line performance monitoring and diagnosis. Chemical Engineering Progress 86(1):60-68. (link )

Cheung, J. and G. Stephanopoulos. 1990. Representation of process trends — Part I. A formal representation framework. Computers & Chemical Engineering 14(4-5):495-510. DOI: 10.1016/0098-1354(90)87023-I. (link )

Cheung, J. and G. Stephanopoulos. 1990. Representation of process trends — Part II. The problem of scale and qualitative scaling. Computers & Chemical Engineering 14(4-5):511-539. DOI: 10.1016/0098-1354(90)87024-J. (link )

Lakshmanan, R. and G. Stephanopoulos. 1990. Synthesis of operating procedures for complete chemical plants — III. Planning in the presence of qualitative, mixing constraints. Computers & Chemical Engineering 14(3):301-317. DOI: 10.1016/0098-1354(90)87068-Z. (link )

Mavrovouniotis, M. L., G. Stephanopoulos and G. Stephanopoulos. 1990. Computer‐aided synthesis of biochemical pathways. Biotechnology and Bioengineering 36(11):1119-1132. DOI: 10.1002/bit.260361107. (link )

Mavrovouniotis, M. L., G. Stephanopoulos and G. Stephanopoulos. 1990. Estimation of upper bounds for the rates of enzymatic reactions. Chemical Engineering Communications 93(1):211-236. DOI: 10.1080/00986449008911447. (link )

Stephanopoulos, G. 1990. Artificial intelligence in process engineering—current state and future trends. Computers & Chemical Engineering 14(11):1250-1270. DOI: 10.1016/0098-1354(90)80006-W. (link )

Stephanopoulos, G., G. Henning and H. Leone. 1990. MODEL.LA. A modeling language for process engineering — I. The formal framework. Computers & Chemical Engineering 14(8):813-846. DOI: 10.1016/0098-1354(90)87040-V. (link )

Stephanopoulos, G., G. Henning and H. Leone. 1990. MODEL.LA. A modeling language for process engineering — II. Multifaceted modeling of processing systems. Computers & Chemical Engineering 14(8):847-869. DOI: 10.1016/0098-1354(90)87041-M. (link )

1989

Fornari, T., E. Rotstein and G. Stephanopoulos. 1989. Studies on the synthesis of chemical reaction paths—II. Reaction schemes with two degrees of freedom. Chemical Engineering Science 44(7):1569-1579. DOI: 10.1016/0009-2509(89)80033-8. (link )

Mavrovouniotis, M. L. and G. Stephanopoulos. 1989. Order-of-magnitude reasoning with O[M]. Artificial Intelligence in Engineering 4(3):106-114. DOI: 10.1016/0954-1810(89)90007-1. (link )

Mavrovouniotis, M. L., G. Stephanopoulos and G. Stephanopoulos. 1989. Formal modeling of approximate relations in biochemical systems. Biotechnology and Bioengineering 34(2):196-206. DOI: 10.1002/bit.260340208. (link )

Sriram, D., G. Stephanopoulos, R. Logcher, D. Gossard, N. Groleau, D. Serrano and D. Navinchandra. 1989. Knowledge-based system applications in engineering design: Research at MIT. AI Magazine 10(3):79. DOI: 10.1609/aimag.v10i3.758. (link )

1988

Calandranis, J. and G. Stephanopoulos. 1988. A structural approach to the design of control systems in heat exchanger networks. Computers & Chemical Engineering 12(7):651-669. DOI: 10.1016/0098-1354(88)80006-1. (link )

Gevelber, M. A., G. Stephanopoulos and M. J. Wargo. 1988. Dynamics and control of the Czochralski process II. Objectives and control structure design. Journal of Crystal Growth 91(1-2):199-217. DOI: 10.1016/0022-0248(88)90386-7. (link )

Lakshmanan, R. and G. Stephanopoulos. 1988. Synthesis of operating procedures for complete chemical plants: Part I. Hierarchical, structured modeling for non-linear planning. Computers & Chemical Engineering 12(9-10):985-1002. DOI: 10.1016/0098-1354(88)87022-4. (link )

Lakshmanan, R. and G. Stephanopoulos. 1988. Synthesis of operating procedures for complete chemical plants—II. A nonlinear planning methodology. Computers & Chemical Engineering 12(9-10):1003-1021. DOI: 10.1016/0098-1354(88)87023-6. (link )

Mavrovouniotis, M. L. and G. Stephanopoulos. 1988. Formal order-of-magnitude reasoning in process engineering. Computers & Chemical Engineering 12(9-10):867-880. DOI: 10.1016/0098-1354(88)87014-5. (link )

1987

Asbjornsen, O. A., T. Takamatsu, G. Stephanopoulos, J. S. Anderson, J. G. Balchen and D. M. Prett. 1987. 7.1 - Chemical process control education. IFAC Proceedings Volumes 20(5):97-99. DOI: 10.1016/S1474-6670(17)55542-1. (link )

Gevelber, M. A. and G. Stephanopoulos. 1987. Dynamics and control of the Czochralski process: I. Modelling and dynamic characterization. Journal of Crystal Growth 84(4):647-668. DOI: 10.1016/0022-0248(87)90056-X. (link )

Gevelber, M. A., M. J. Wargo and G. Stephanopoulos. 1987. Advanced control design considerations for the Czochralski process. Journal of Crystal Growth 85(1-2):256-263. DOI: 10.1016/0022-0248(87)90232-6. (link )

Stephanopoulos, G. 1987. Future of expert systems in chemical engineering. Chemical Engineering Progress 83(9):44-51. (link )

Stephanopoulos, G. and H. Huang. 1987. Two-port control system: A generalized predicitive controller. International Journal of Control 45(2):617-639. DOI: 10.1080/00207178708933755. (link )

Stephanopoulos, G., J. Johnston, T. Kriticos, R. Lakshmanan, M. Mavrovouniotis and C. Siletti. 1987. DESIGN-KIT: An object-oriented environment for process engineering. Computers& Chemical Engineering 11(6):655-674. DOI: 10.1016/0098-1354(87)87010-2. (link )

Stephanopoulos, G., J. Johnston, R. Lakshmanan and R. Stewart. 1987. An intelligent system for planning plant-wide process control strategies. IFAC Proceedings Volumes 20(5, Part 7):231-238. DOI: 10.1016/S1474-6670(17)55152-6. (link )

1986

Calandranis, J. and G. Stephanopoulos. 1986. Structural operability analysis of heat exchanger networks. Chemical Engineering Research and Design 64(5):347-264. (link )

Gani, R., J. A. Romagnoli and G. Stephanopoulos. 1986. Control studies in an extractive distillation process: Simulation and measurement structure. Chemical Engineering Communications 40(1-6):281-302. DOI: 10.1080/00986448608911703. (link )

Stephanopoulos, G. 1986. A Research Program ON: Artificial intelligence in process engineering. Chemical Engineering Education XX(4):182-192. (link )

Stephanopoulos, G. and H. Huang. 1986. The 2-port control system. Chemical Engineering Science 41(6):1611-1630. DOI: 10.1016/0009-2509(86)85241-1. (link )

Stephanopoulos, G. and G. Stephanopoulos. 1986. Artificial intelligence in the development and design of biochemical processes. Trends in Biotechnology 4(9):241-249. DOI: 10.1016/0167-7799(86)90118-6. (link )

Stephanopoulos, G. and D. W. Townsend. 1986. Synthesis in process development. Chemical Engineering Research and Design 64(3):160-174. (link )

1983

Stephanopoulos, G. 1983. Synthesis of control systems for chemical plants: A challenge for creativity. Computers & Chemical Engineering 7(4):331-365. DOI: 10.1016/0098-1354(83)80018-0. (link )

1982

Alvarez, J. and G. Stephanopoulos. 1982. An estimator for a class of non-linear distributed systems. International Journal o Control 36(5):787-802. DOI: 10.1080/00207178208932930. (link )

Rotstein, E., D. Resasco and G. Stephanopoulos. 1982. Studies on the synthesis of chemical reaction paths—I: Reaction characteristics in the (ΔG, T) space and a primitive synthesis procedure. Chemical Engineering Science 37(9):1337-1352. DOI: 10.1016/0009-2509(82)85006-9. (link )

Seigneur, C., G. Stephanopoulos and R. W. Carr Jr. 1982. Dynamic sensitivity analysis of chemical reaction systems: A variational method. Chemical Engineering Science 37(6):845-853. DOI: 10.1016/0009-2509(82)80172-3. (link )

Svoronos, S. and G. Stephanopoulos. 1982. On the behaviour of two stirred tanks in series. Chemical Engineering Science 37(3):357-366. DOI: 10.1016/0009-2509(82)80087-0. (link )

Tsoukas, A., M. Tirrell and G. Stephanopoulos. 1982. Multiobjective dynamic optimization of semibatch copolymerization reactors. Chemical Engineering Science 17(12):1785-1795. DOI: 10.1016/0009-2509(82)80050-X. (link )

1981

Alvarez, J., J. A. Romagnoli and G. Stephanopoulos. 1981. Variable measurement structures for the control of a tubular reactor. Chemical Engineering Science 36(10):1695-1712. DOI: 10.1016/0009-2509(81)80015-2. (link )

Arkun, Y. and G. Stephanopoulos. 1981. Studies in the synthesis of control structures for chemical processes. Part V: Design of steady‐state optimizing control structures for integrated chemical plants. AIChE Journal 27(6):779-793. DOI: 10.1002/aic.690270512. (link )

Michalopoulos, P. G., G. Stephanopoulos and G. Stephanopoulos. 1981. An application of shock wave theory to traffic signal control. Transportation Research Part B: Methodological 15(1):353-51. DOI: 10.1016/0191-2615(81)90045-X. (link )

Nashida, N., G. Stephanopoulos and A. W. Westerberg. 1981. A review of process synthesis. AIChE Journal 27(3):321-351. DOI: 10.1002/aic.690270302. (link )

Romagnoli, J., J. Alvarez and G. Stephanopoulos. 1981. Variable measurement structures for process control. International Journal of Control 33(2):269-289. DOI: 10.1080/00207178108922923. (link )

Romagnoli, J. A. and G. Stephanopoulos. 1981. Rectification of process measurement data in the presence of gross errors. Chemical Engineering Science 36(11):1849-1863. DOI: 10.1016/0009-2509(81)80133-9. (link )

Svoronos, S., G. Stephanopoulos and R. Aris. 1981. On bilinear estimation and control. International Journal of Control 34(4):651-684. DOI: 10.1080/00207178108922554. (link )

1980

Morari, M., Y. Arkun and G. Stephanopoulos. 1980. Studies in the synthesis of control structures for chemical processes: Part I: Formulation of the problem. Process decomposition and the classification of the control tasks. Analysis of the optimizing control structures. AIChE Journal 26(2):220-232. DOI: 10.1002/aic.690260205. (link )

Morari, M. and G. Stephanopoulos. 1980. Minimizing unobservability in inferential control schemes. nternational Journal of Control 31(2):367-377. DOI: 10.1080/00207178008961047. (link )

Morari, M. and G. Stephanopoulos. 1980. Studies in the synthesis of control structures for chemical processes: Part II: Structural aspects and the synthesis of alternative feasible control schemes. AIChE Journal 26(2):232-246. DOI: 10.1002/aic.690260206. (link )

Morari, M. and G. Stephanopoulos. 1980. Studies in the synthesis of control structures for chemical processes: Part III: Optimal selection of secondary measurements within the framework of state estimation in the presence of persistent unknown disturbances. AIChE Journal 26(2):247-260. DOI: 10.1002/aic.690260207. (link )

Romagnoli, J. A. and G. Stephanopoulos. 1980. On the rectification of measurement errors for complex chemical plants: Steady state analysis. Chemical Engineering Science 353(5):1067-1081. DOI: 10.1016/0009-2509(80)85096-2. (link )

Sophos, A., E. Rotstein and G. Stephanopoulos. 1980. Multiobjective analysis in modeling the petrochemical industry. Chemical Engineering Science 35(12):2415-2426. DOI: 10.1016/0009-2509(80)85054-8. (link )

Sophos, A., E. Rotstein and G. Stephanopoulos. 1980. Thermodynamic bounds and selection of technologies in the petrochemical industry. Chemical Engineering Science 35(5):1049-1065. DOI: 10.1016/0009-2509(80)85095-0. (link )

1979

Morari, M., G. Stephanopoulos and R. Aris. 1979. Stability analysis of structured chemical engineering systems via decomposition. Chemical Engineering Science 34(1):11-15. DOI: 10.1016/0009-2509(79)85173-8. (link )

Stephanopoulos, G., P. G. Michalopoulos and G. Stephanopoulos. 1979. Modelling and analysis of traffic queue dynamics at signalized intersections. Transportation Research Part A: General 13(4):295-307. DOI: 10.1016/0191-2607(79)90028-1. (link )

Stephanopoulos, G., I. M. Schuelke and G. Stephanopoulos. 1979. A decomposition method for the stability analysis of large microbial systems. Theoretical Population Biology 16(2):126-143. DOI: 10.1016/0040-5809(79)90009-1. (link )

1978

Michalopoulos, P. G. and G. Stephanopoulos. 1978. Optimal control of oversaturated intersections: Theoretical and practical considerations. Traffic Engineering and Control 19(5):216-221. (link )

Morari, M. and G. Stephanopoulos. 1978. Comments on finding the generic rank of a structural matrix. IEEE Transactions on Automatic Control 23(3):409-510. DOI: 10.1109/TAC.1978.1101732. (link )

1977

Michalopoulos, P. G. and G. Stephanopoulos. 1977. Oversaturated signal systems with queue length constraints—I: Single intersection. Trasnportation Research 11(6):413-421. DOI: 10.1016/0041-1647(77)90006-5. (link )

Michalopoulos, P. G. and G. Stephanopoulos. 1977. Oversaturated signal systems with queue length constraints—II: Systems of intersections. Transportation Research 11(6):423-428. DOI: 10.1016/0041-1647(77)90007-7. (link )

1976

Stephanopoulos, G. and A. W. Westerberg. 1976. Studies in process synthesis—II: Evolutionary synthesis of optimal process flowsheets. Chemical Engineering Science 31(3):195-204. DOI: 10.1016/0009-2509(76)85057-9. (link )

1975

Johnson, A. I., A. Lozada, M. Anvari, G. Stephanopoulos and P. Weng. 1975. Steady state and dynamic studies of a multi product chemical plant. The Canadian Journal of Chemical Engineering 53(3):340-346. DOI: 10.1002/cjce.5450530317. (link )

Stephanopoulos, G. 1975. A note on the optimization of constrained design problems. Journal of Optimization theory and Applications 17(3-4):337-345. DOI: 10.1007/BF00933883. (link )

Stephanopoulos, G. and A. W. Westerberg. 1975. Synthesis of optimal process flowsheets by an infeasible decomposition technique in the presence of functional non‐convexities. The Canadian Journal of Chemical Engineering 53(5):551-555. DOI: 10.1002/cjce.5450530515. (link )

Stephanopoulos, G. and A. W. Westerberg. 1975. The use of Hestenes' method of multipliers to resolve dual gaps in engineering system optimization. Journal of Optimization Theory and Applications 15:285-309. DOI: 10.1007/BF00933339. (link )

Westerberg, A. W. and G. Stephanopoulos. 1975. Studies in process synthesis—I: Branch and bound strategy with list techniques for the synthesis of separation schemes. Chemical Engineering Science 30(8):963-972. DOI: 10.1016/0009-2509(75)80063-7. (link )

1974

Westerberg, A. W. and G. Stephanopoulos. 1974. A stronger version of the discrete minimum principle. Industial and Engineering Chemistry Fundamentals 13(3):231-237. DOI: 10.1021/i160051a013. (link )

Books

1995

Stephanopoulos, G. and C. Han eds. 1995. Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

1983

Stephanopoulos, G. 1983. Chemical Process Control: An Introduction to Theory and Practice. Prentice Hall Press. ISBN: 978-0131286290.

Book Chapters

2019

Ashraf, M. T., A. Ines Torres, J. E. Schmidt and G. Stephanopoulos. 2019. Analysis and optimization of multi-actor biorefineries. Pp. 49-75 In: Bastidas-Oyanedel, J. and J. E. Schmidt eds., Biorefinery. Springer. Cham. DOI: 10.1007/978-3-030-10961-5_3. ISBN: 978-3-030-10960-8. (link )

2017

Ines Torres, A., M. T. Ashraf, T. Chaturvedi, J. E. Schmidt and G. Stephanopoulos. 2017. Hydrothermal pretreatment: Process modeling and economic assessment within the framework of biorefinery processes. Pp. 207-235 In: Ruiz, H. A., M. Hedegaard Thomsen and H. L. Trajano eds., Hydrothermal Processing in Biorefineries: Production of Bioethanol and High Added-Value Compounds of Second and Third Generation Biomass. Springer International Publishing AG. DOI: 10.1007/978-3-319-56457-9. ISBN: 978-3-319-56456-2.

2016

Ashraf, M. T., A. Ines Torres, I. Cybulska, C. Fang, M. Hedegaard Thomsen, J. E. Schmidt and G. Stephanopoulos. 2016. Optimization of lignocellulosic using multi-actor multi-objective biorefinery framework. Pp. 1317-1323 In: Kravanja, Z. ed., 26th European Symposium on Computer Aided Process Engineering. Vol 38. Elseiver. ISBN: 9780444634283.

Ashraf, M. T., J. E. Schmidt and G. Stephanopoulos. 2016. Evaluation of the production of lipids for fuels and proteins from microalgae by decomposition of the processing network. Pp. 1617-1623 In: Kravanja, Z. ed., 26th European Symposium on Computer Aided Process Engineering. Vol 38. Elsevier. ISBN: 9780444634283.

Ines Torres, A., T. Bochenski, J. E. Schmidt and G. W. Stephanopoulos. 2016. Economically optimal multi-actor processing networks: material flows and price assignment of the intermediates using Lagrangian decomposition. Pp. 1383-1388 In: Kravanja, Z. ed., 26th European Symposium on Computer Aided Process Engineering. Vol 38. Elsevier. ISBN: 9780444634283.

2015

Ines Torres, A., I. Cybulska, C. Fang, M. Hedegaard Thomsen, J. E. Schmidt and G. W. Stephanopoulos. 2015. A novel approach for the identification of economic opportunities within the framework of a biorefinery. Pp. 1175-1180 In: Gernaey, K. V., J. K. Huusom and R. Gani eds., 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering. Vol 37. Elsevier. ISBN: 9780444634290.

2010

Solis, E. O., P. I. Barton and G. Stephanopoulos. 2010. Chapter 8. Principles and methdologies for the controlled formation of self-assmbled nanoscale structures with desired geometries. Pp. 233-265 In: Pistikopoulos, E. N., M. C. Georgiadis and V. Dua eds., Peocess Systems Engineering. Vol 6. John Wiley & Sons. DOI: 10.1002/9783527631209.ch59. ISBN: 9783527316847.

2009

Solis, E. O., P. I. Barton and G. Stephanopoulos. 2009. Controlled formation of self-assembled nanostructures with desired geometries: Robust dynamic paths to robust desired structures. Pp. 1713-1718 In: de Brito Alves, R., C. A. Oller do Nascimento and E. C. Biscaia Jr eds., 10th International Symposium on Process Systems Engineering: Part A. Vol 27. Elsevier. DOI: 10.1016/S1570-7946(09)70676-5. ISBN: 978-0-444-53472-9.

Stephanopoulos, G. W. 2009. Process systems engineering: From Solvay to the 21st century.: A history of development, successes and prospects for the future. Pp. 149-155 In: de Brito Alves, R., C. A. Oller do Nascimento and E. C. Biscaia Jr eds., 10th International Symposium on Process Systems Engineering: Part A. Vol 27. Elsivier. ISBN: 978-0-444-53472-9.

1999

Stephanopoulos, G. 1999. Multi-scale approaches in engineering and scientific computing. Pp. 77-92 In: Keil, F., W. Mackens, H. Voss and J. Werther eds., Scientific Computing in Chemical Engineering II: Simulation, Image Processing, Optimization, and Control. Vol 2. Springer. ISBN: 978-3540658511.

1998

Stephanopoulos, G., O. Karsligil and M. Dyer. 1998. Multi-scale aspects in lnear and nonlinear estimation and control. Pp. 667-734 In: Berber, R. and C. Kravaris eds., Nonlinear Model Based Process Control. Vol 353. Springer. Dordrecht. ISBN: 978-94-010-6140-7. (link )

1995

Bakshi, B. R. and G. Stephanopoulos. 1995. Reasoning in time: Modeling, analysis, and pattern recognition of temporal process trends. Pp. 487-549 In: Stephanopoulos, G. and C. Han eds., Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design.. Vol 22. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

Han, C., R. Lakshmanan, B. R. Bakshi and G. Stephanopoulos. 1995. Nonmonotonic reasoning: The synthesis of operating procedures in chemical plants. Pp. 314-377 In: Stephanopoulos, G. and C. Han eds., Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design. Vol 22. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

Han, C. and G. Stephanopoulos. 1995. Integrating information, management and control in process industries. Pp. 715-751 In: Berber, R. ed., Methods of Model Based Process Control. Springer. ISBN: 978-94-011-0135-6.

Han, C., G. Stephanopoulos and J. M. Douglas. 1995. Automation in design: The conceptual synthesis of chemical processing systems. Pp. 94-147 In: Stephanopoulos, G. and C. Han eds., Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design. Vol 21. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

Joback, K. G. and G. Stephanopoulos. 1995. Searching spaces of discrete solutions: The design of molecules possessing desired physical properties. Pp. 258-610 In: Stephanopoulos, G. and C. Han eds., Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design. Vol 21. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

Koulouris, A., B. R. Bakshi and G. Stephanopoulos. 1995. Empirical learning through neural networks: The wave-net solution. Pp. 438-486 In: Stephanopoulos, G. and C. Han eds., Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design. Vol 22. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

Linninger, A., S. Ali, E. Stephanopoulos, C. Han and G. Stephanopoulos. 1995. Synthesis and assessment of batch processes for pollution prevention. Pp. 46-58 In: El Halwagi, M. and D. Petrides eds., Pollution Prevention via Process and Product Modifications. Vol 90. AIChE.

Nagel, C. J., C. Han and G. Stephanopoulos. 1995. Modeling languages: Declarative and imperative descriptions of chemical reactions and processing systems. Pp. 2-93 In: Stephanopoulos, G. and C. Han eds., Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design. Vol 21. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

Nagel, C. J. and G. Stephanopoulos. 1995. Inductive and deductive reasoning: The case of identifying potential hazards in chemical processes. Pp. 188-257 In: Stephanopoulos, G. and C. Han eds., Intelligent Systems in Process Engineering. Part I: Paradigms from Product and Process Design. Vol 21. Academic Press. San Diego, CA and London, UK. ISBN: 978-0120085217.

1994

Bakshi, B. R., A. Koulouris and G. Stephanopoulos. 1994. Learning at multiple resolutions through Wave-Nets and inductive decision trees. Pp. Chapter V In: Motard, R. L. and B. Joseph eds., Wavelet Applications in Chemical Engineering. Springer Verlag. New York, NY. ISBN: 9781461361664.

1992

Siletti, C. A. and G. Stephanopoulos. 1992. Chapter 10 - BioSep Designer: A process synthesizer for bioseparations. Pp. 295-316 In: Tong, C. and D. Sriram eds., Atificial Intelligence in Engineering Design Volume : Design Representation and Models of Routine Design. Vol 1. Academic Press. ISBN: 978-0-12-660561-7.

1991

Stephanopoulos, G. 1991. Chapter 16. Symbolic computing and artificial intelligence in chemical engineering: A new challenge. Pp. 543-552 In: Colton, C. K. ed., Perspectives in Chemical Engineering: Research and Education. Vol 16. ISBN: 978-0-12-008516-3.

1988

Stephanopoulos, G. 1988. The scope of artificial intelligence in plant-wide operations. In: Reklaitis, G. V. and H. D. Spriggs eds., Foundations of Computer Aided Process Operations: Proceedings of the First International Conference on Foundations of Computer Aided Process Operati. Elseivier. ISBN: 978-0444989253.

1987

Stephanopoulos, G., J. Johnston and R. Lakshmanan. 1987. An artificial intelligence perspective in the design of control systems for complete chemical process. Pp. 49-78 In: Prett, D. M. and M. Morari eds., Shell Process Control Workshop. Butterworth Publishers. ISBN: 978-0409901368.

Conference Papers

2006

Karsligil, O. and G. Stephanopoulos. 2006. The multiscale nature of process dynamics and model-predictive control. 2006 6th World Congress on Intelligent Control and Automation. 6th World Congress on Intelligent Control and Automation. Dalian, China. (link )

1992

Bakshi, B. R. and G. Stephanopoulos. 1992. Wavelets as basis functions for localized learning in a multi-resolution hierarchy. Proceedings of the International Joint Conference on Neural Networks. International Joint Conference on Neural Networks. Baltimore, MD. (link )

1991

Stephanopoulos, G. 1991. Multi-scale descriptions of real-time trends and their impact in pattern recognition. 1991 American Control Conference. 1991 American Control Conference. Boston, MA.

1989

Joback, K. G. and G. Stephanopoulos. 1989. Designing molecules processing desired physical property values. In: Siirola, J. J., I. E. Grossman and G. Stephanopoulos eds., Foundations of Computer-aided Process Design: Proceedings of the Third International Conference on Foundations of Computer-Aided Process Design. Third International Conference on Foundations of Computer-Aided Process Design. Snowmass Village, CO.

Stephanopoulos, G. 1989. Artificial intelligence and symbolic computing in process engineering design. In: Siirola, J. J., I. E. Grossman and G. Stephanopoulos eds., Foundations of Computer-aided Process Design: Proceedings of the Third International Conference on Foundations of Computer-Aided Process Design. Third International Conference on Foundations of Computer-Aided Process Design. Snowmass Village, CO.

1987

Mavrovouniotis, M. L. and G. Stephanopoulos. 1987. Reasoning with orders of magnitude and approximate relations. Pp. 626-630 AAAI-87 Proceedings. (link )

1985

Huang, H. and G. Stephanopoulos. 1985. Adaptive design of model-based controllers. Pp. 1520 Proceedings of the 1985 American Control Conference. 1985 American Control Conference. Boston, MA. (link )